Dosing and different administration approaches are performed based on extensive literature and in vitro research. Maximal tolerated dose is determined with care and intensive monitoring. PK studies are ordinarily performed and timely samples collection with high care for high quality samples suitable for downstream analysis of tissue content of either small molecule, biological compound, metabolites or RNA sequences. Strictly keeping the cold chain, at storage and delivery as needed. Samples are carefully wrapped and sent to the specified analytical laboratory.
Safety studies of new drugs are performed including clinical observation and careful estimation of physiological parameters, As instructed by the Ethical approval humane euthanasia and necropsy are performed with certified pathologist if requested and organs are collected for Validating the safety of new drugs to each of the organs.
